It would be easy to dismiss it as a cliched statement of the all-too-obvious. Yes, we live in a dangerous world where there are communication problems on all levels. Misunderstandings can escalate and lead to unimaginable catastrophe. But it's a movie - a visual medium - so it shows us how this can happen. It takes us to places where we've never been: a Moroccan village, a raucous Mexican wedding, a girls basketball game in a Tokyo school for the deaf. And the acting is faultless - with an almost unmanageably large cast.
Curiously, the most profound miscommunication seemed to be at the family level - most specifically, between parents and children. Surely there's a message there.
If I had one quibble it would be (SPOILER FOLLOWS)
that you really need to stretch to think that the Jones (Pitt/Blanchett) family could be visited by so much tragedy in such a short time: lose an infant to SIDS, then Mom gets shot on a tour bus, then within days, the family children are lost in the burning California desert. This is starting to look more like the story of Job - not Babel.